Since 1997 the MOSIM conference has been a regular exchange place fir researchers, academics and people frim industry in the area of modeling, optimization and simulation of (idustrial, transport, health, urban…) systems. MOSIM 2020 will be the 13th edition of this biennale conference. The main theme of this edition will be be “New advances and challenges for sustinable and smart industries”. New topics such as Industry 4.0, IoT, Big Data and Data Analytics will be addressed. The aim of MOSIM is to foster theroical and/or methodological results but also to encourage presentation of emergin and timely case studies.